piRNA biogenesis during adult spermatogenesis in mice is independent of the ping-pong mechanism
نویسندگان
چکیده
منابع مشابه
Histone-derived piRNA biogenesis depends on the ping-pong partners Piwi5 and Ago3 in Aedes aegypti
The piRNA pathway is of key importance in controlling transposable elements in most animal species. In the vector mosquito Aedes aegypti, the presence of eight PIWI proteins and the accumulation of viral piRNAs upon arbovirus infection suggest additional functions of the piRNA pathway beyond genome defense. To better understand the regulatory potential of this pathway, we analyzed in detail hos...
متن کاملproceed via the Ping-Pong mechanism
Acyl-transfer catalysed by y-glutamyltranspeptidase from bovine kidney was studied using y-Land y-D-Glu-p-nitroanilide as the donor and GlyGly as the acceptor. The transfer of the y-Glu group to GlyGly was shown to be accompanied by transfer of the y-Glu group to water (hydrolysis). The results were compared with acyl-transfer catalysed by the representative serine protease, a-chymotrypsin. The...
متن کاملpiRNA and spermatogenesis in mice.
Transposable elements and their fossil sequences occupy about half of the genome in mammals. While most of these selfish mobile elements have been inactivated by truncations and mutations during evolution, some copies remain competent to transpose and/or amplify, posing an ongoing genetic threat. To control such mutagenic sequences, host genomes have developed multiple layers of defence mechani...
متن کاملProduction of Virus-Derived Ping-Pong-Dependent piRNA-like Small RNAs in the Mosquito Soma
The natural maintenance cycles of many mosquito-borne pathogens require establishment of persistent non-lethal infections in the invertebrate host. The mechanism by which this occurs is not well understood, but we have previously shown that an antiviral response directed by small interfering RNAs (siRNAs) is important in modulating the pathogenesis of alphavirus infections in the mosquito. Howe...
متن کاملPing pong in the pore
Getting to the inner circle ontiguity between the ER and the nuclear envelope means nuclear membrane proteins have a direct shot to their target. In fact, inner nuclear membrane (INM) proteins were thought to need only to diffuse to the nucleus, pass through the nuclear pore, and then be retained by nuclear-localized binding partners. But new results suggest a more active process. Suraj Saksena...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2012
ISSN: 1001-0602,1748-7838
DOI: 10.1038/cr.2012.120